我院2018年度春季学期学术系列讲座之十一
题目：Epigenetic switching and antisense transcription
讲座人：Prof Caroline Dean
Project Leader
Cell and Developmental Biology
The John Innes Centre
Officer of the Order of the British Empire
Fellow of the Royal Society
Member of United States National Academy of Sciences
时间：2018年6月1日（星期五），13:00-14:30
地点：新葡萄8883官网AMG邓祐才报告厅 
主持人：钱伟强研究员 
摘要：
Chromatin regulation and non-coding transcription are now seen as major factors regulating gene expression in most eukaryotic genomes. Through the study of how plants time developmental transitions, we have discovered that Arabidopsis floral repressor FLC is an excellent system in which to dissect how non-coding transcription and chromatin mechanisms regulate gene expression. FLC expression is quantitatively modulated by an antisense-mediated chromatin mechanism that coordinately influences transcription initiation and elongation. Expression is then epigenetically silenced through a cold-induced, cis-based, Polycomb switching mechanism. The talk will describe our latest understanding of these conserved mechanisms and how they have been modulated during adaptation.
欢迎各位老师同学积极参加！